反应详情

5-Benzyloxy-2-fluoro-4-methyl-1-nitrobenzene (500 mg, 1.9 mmol) in methanol (10 ml) was added to a suspension of Raney nickel (75 mg) and hydrazine hydrate (465 ml, 9.5 mmol) in methanol (10 ml) and heated at reflux. The mixture was maintained under reflux for 15 minutes and then the insoluble materials removed by filtration through diatomaceous earth. The filter pad was washed with methanol and the solvent removed from the filtrate by evaporation to give 5-benzyloxy-2-fluoro-4-methylaniline (440 mg, 99%).

1. temperatureheated
2. temperatureat reflux
3. temperatureThe mixture was maintained
4. temperatureunder reflux for 15 minutes
5. customthe insoluble materials removed by filtration through diatomaceous earth
6. washThe filter pad was washed with methanol
7. customthe solvent removed from the filtrate by evaporation