反应详情

温度

100 °C

A mixture of 6-methoxy-7-(2-methylthioethoxy)-4-phenoxyquinazoline (1.5 g, 4.4 mmol) and 2M hydrochloric acid (25 ml) was heated at 100° C. for 2 hours. The mixture was allowed to cool, and methylene chloride was added with stirring to give a white precipitate. The precipitate was collected by filtration, washed with water and methylene chloride and dried to give 6-methoxy-7-(2-methylthioethoxy)-3,4-dihydroquinazolin-4-one hydrochloride (1.1 g, 83%).

1. temperatureto cool
2. customto give a white precipitate
3. filtrationThe precipitate was collected by filtration
4. washwashed with water and methylene chloride
5. customdried