Hydrochloric Acid → 6-Methoxy-7-(2-methylthioethoxy)-3,4-dihydroquinazolin-4-one hydrochloride

HRID 634696Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][S:16][CH3:17])[N:9]=[CH:8][N:7]=[C:6]2[O:18]C1C=CC=CC=1.[ClH:25]>C(Cl)Cl>[ClH:25].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][S:16][CH3:17])[N:9]=[CH:8][NH:7][C:6]2=[O:18]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of 6-methoxy-7-(2-methylthioethoxy)-4-phenoxyquinazoline (1.5 g, 4.4 mmol) and 2M hydrochloric acid (25 ml) was heated at 100° C. for 2 hours. The mixture was allowed to cool, and methylene chloride was added with stirring to give a white precipitate. The precipitate was collected by filtration, washed with water and methylene chloride and dried to give 6-methoxy-7-(2-methylthioethoxy)-3,4-dihydroquinazolin-4-one hydrochloride (1.1 g, 83%).

Workup

temperatureto cool
customto give a white precipitate
filtrationThe precipitate was collected by filtration
washwashed with water and methylene chloride
customdried

Sources & evidence

ORD record: ord-98486ddbb3a9462fb5adfc6a339eb780
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06184225B2

Reaction notes

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