HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-6-methoxy-7-(2-piperidinoethoxy)quinazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-Methoxy-7-(2-piperidinoethoxy)-3,4-dihydroquinazolin-4-one | HCID 135542437 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-6-methoxy-7-(2-piperidinoethoxy)quinazoline hydrochloride | HCID 22030810 | — |
Reaction Steps
A mixture of 6-methoxy-7-(2-piperidinoethoxy)-3,4-dihydroquinazolin-4-one (440 mg, 1.45 mmol), thionyl chloride (15 ml) and DMF (3 drops) was heated at reflux for 3 hours then allowed to cool. The excess thionyl chloride was removed by evaporation and the residue was azeotroped with toluene to give a crude 4-chloro-6-methoxy-7-(2-piperidinoethoxy)quinazoline hydrochloride (640 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06184225B2 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-1073554ccb1d4c229ed843d382251661 |
| Source note | uspto-grants-2001_02 |