反应详情

A mixture of 6-methoxy-7-(2-piperidinoethoxy)-3,4-dihydroquinazolin-4-one (440 mg, 1.45 mmol), thionyl chloride (15 ml) and DMF (3 drops) was heated at reflux for 3 hours then allowed to cool. The excess thionyl chloride was removed by evaporation and the residue was azeotroped with toluene to give a crude 4-chloro-6-methoxy-7-(2-piperidinoethoxy)quinazoline hydrochloride (640 mg).

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. temperatureto cool
4. customThe excess thionyl chloride was removed by evaporation
5. customthe residue was azeotroped with toluene