反应详情

1M Aqueous sodium hydroxide solution (4 ml, 4 mmol) was added to a solution of 4-(2-fluoro-5-methoxycarbonyloxy4-methylanilino)-7-hydroxy-6-methoxyquinazoline (820 mg, 2.2 mmol) in methanol (20 ml) and the mixture stirred for 1 hour at ambient temperature. Concentrated hydrochloric acid (0.8 ml) was added, the volatiles removed by evaporation and the residue purified by column chromatography eluting with methylene chloride/methanol (60/40) to give 4-(2-fluoro-5-hydroxy4-methylanilino)-7-hydroxy-6-methoxyquinazoline (313 mg, 45%).

1. customthe volatiles removed by evaporation
2. customthe residue purified by column chromatography
3. washeluting with methylene chloride/methanol (60/40)