反应详情

A solution of 7-benzyloxy4-chloro-6-methoxyquinazoline (800 mg, 2.6 mmol), (prepared as described for the starting material in Example 4 but with an aqueous work up), and 2-fluoro-5-methoxycarbonyloxy-4-methylaniline (570 mg, 2.89 mmol) in isopropanol (20 ml) was refluxed for 2 hours. After cooling to ambient temperature, the solid was filtered, washed with isopropanol and dried under vacuum to give 7-benzyloxy-4-(2-fluoro-5-methoxycarbonyloxy4-methylanilino)-6-methoxyquinazoline (1.0 g, 77%).

1. temperaturewas refluxed for 2 hours
2. filtrationthe solid was filtered
3. washwashed with isopropanol
4. customdried under vacuum