反应详情

温度

0 °C

A solution of 2-amino-5-methoxy-4-nitrobenzoic acid (1 6.6 g, 78 mmol) in formamide (250 ml) was heated at reflux for 4.5 hours. The reaction mixture was cooled to 0° C., diluted with water and the resulting precipitate collected by filtration, washed with water and dried under vacuum to give 6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one ( 11.56 g, 67%).

1. temperatureat reflux for 4.5 hours
2. filtrationthe resulting precipitate collected by filtration
3. washwashed with water
4. customdried under vacuum