HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 634741Generated: October 30, 2026
Formamide → 6-Methoxy-7-nitroquinazolin-4(3H)-one
https://huagongshe.com/reaction/634741
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 2-Amino-4-nitro-5-methoxybenzoic Acid | HCID 21260273 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Methoxy-7-nitroquinazolin-4(3H)-one | HCID 135452004 | 67% |
Reaction Steps
A solution of 2-amino-5-methoxy-4-nitrobenzoic acid (1 6.6 g, 78 mmol) in formamide (250 ml) was heated at reflux for 4.5 hours. The reaction mixture was cooled to 0° C., diluted with water and the resulting precipitate collected by filtration, washed with water and dried under vacuum to give 6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one ( 11.56 g, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06184225B2 |
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| Source dataset | uspto-grants-2001_02 |
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| ORD ID | ord-ed43d6a74e77410e8317dfed80d62c92 |
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| Source note | uspto-grants-2001_02 |
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