反应详情

A suspension of 6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one (8 g, 36 mmol) in thionyl chloride (150 ml) and DMF (0.8 ml) was heated at reflux for 3 hours. Excess thionyl chloride was removed by evaporation and the residue azeotroped with toluene. The resulting solid was triturated with ether, collected by filtration and dried under vacuum to give 4-chloro-6-methoxy-7-nitroquinazoline hydrochloride(7.5 g, 75%).

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. customExcess thionyl chloride was removed by evaporation
4. customthe residue azeotroped with toluene
5. customThe resulting solid was triturated with ether
6. filtrationcollected by filtration
7. customdried under vacuum