反应详情

A mixture of 7-(2-bromoethoxy)-6-methoxy-4-phenoxyquinazoline (1.1 g, 2.9 mmol), (prepared as described for the starting material in Example 22), in 2-methoxyethylamine (8 ml) was stirred at ambient temperature for 4 hours. The mixture was diluted with water and extracted with methylene chloride (5×25 ml). The combined extracts were washed with brine and passed through phase separating paper. The solvent was removed by evaporation and the residue purified by column chromatography eluting with methylene chloride/methanol/aqueous ammonia (100/8/1) to give 6-methoxy-4-phenoxy-7-(2-(2-methoxyethylamino)ethoxy)quinazoline (760 mg, 70%) as a white solid.

1. custom(prepared
2. extractionextracted with methylene chloride (5×25 ml)
3. washThe combined extracts were washed with brine
4. customseparating paper
5. customThe solvent was removed by evaporation
6. customthe residue purified by column chromatography
7. washeluting with methylene chloride/methanol/aqueous ammonia (100/8/1)