Aluminium lithium hydride → HCID 21260490, compound

HRID 634782Notes

Reaction equation

HRID 634782 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][CH:18]([NH:21][C:22](=O)[CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]([CH3:33])([CH3:32])[CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]([CH3:33])([CH3:32])[CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21260544HCID 21260544, compound

Product 1

HCID 21260490HCID 21260490, compound

Procedure

Following the procedure of example 40b, (RS)-N-[1-(4-benzyloxy-phenyl)-3,3-dimethyl-piperidin-4-yl]-3-phenyl-propionamide (450 mg) was reduced with LiAlH4 to give (RS)-[1-(4-benzyloxy-phenyl)-3,3-dimethyl-piperidin-4-yl]-(3-phenyl-propyl)-amine as a white solid (260 mg; 60%, MS: m/e=429.4 (M+H+)).

Sources & evidence

ORD record
ord-852b76282eb745b8ab49758a776d2f10
Source dataset
uspto-grants-2001_02
Patent number
US06184236B2

Reaction notes

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