Hydrogen Bromide → HCID 11013999, compound

HRID 634882Notes

Reaction equation

HRID 634882 reaction equation
C(O[CH:5]1[O:14][C@@H:13]([CH3:15])[C@@H:12]([NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])[C@@H:7]([O:8][C:9](=[O:11])[CH3:10])[C@H:6]1[F:23])(=O)C.C(O[C@@H]1O[C@@H](C)[C@@H](NC(=O)C(F)(F)F)[C@@H](OC(=O)C)[C@H]1F)(=O)C.O[C@H]1O[C@@H](CO)[C@@H](O)[C@@H](O)[C@H]1O.[BrH:59]>C(O)(=O)C>[C:9]([O:8][C@@H:7]1[C@H:12]([NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])[C@H:13]([CH3:15])[O:14][C@@H:5]([Br:59])[C@@H:6]1[F:23])(=[O:11])[CH3:10]

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 7043897HCID 7043897, compoundHCID 15885013HCID 15885013, compoundHCID 54376111HCID 54376111, compound

Product 1

HCID 11013999HCID 11013999, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1,3-Di-O-acetyl-2,4,6-trideoxy-2-fluoro-4-(trifluoroacetamido)-L-talopyranose [the mixture of Compounds (11) and (12)] (335 mg) obtained in Example 1-(8) above was dissolved in 3.4 ml of a solution of 30% hydrogen bromide in acetic acid. The resultant solution was allowed to stand at room temperature for 1 hour to effect the bromination reaction.

Workup

  1. customthe bromination reaction

Sources & evidence

ORD record
ord-e745d4b5109d44419c0d5c39a832fad5
Source dataset
uspto-grants-2001_02
Patent number
US06184365B2

Reaction notes

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