反应详情

60 g (0.25 mol) N-ethyl-2,2,4-trimethyl-7-methoxy-1,2-dihydroquinoline was dissolved in 150 ml glacial acetic acid and 150 ml hydrobromic acid was added. The solution was refluxed for 24 h. The cooled solution was stirred in an ice/methanol bath. Subsequently the precipitate was filtered and washed several times with acetone. Colourless crystals were formed in a yield of 85%.

1. temperatureThe solution was refluxed for 24 h
2. filtrationSubsequently the precipitate was filtered
3. washwashed several times with acetone
4. customColourless crystals were formed in a yield of 85%