Hydrochloric Acid → HCID 178525233, compound

Participants

Reaction Steps

In 366 ml of water was suspended 185 g (0.91 mol) of 4-ethoxycarbonylmethyl-2-mercaptothiazole and 366 ml (1.84 mols) of an aqueous solution of 5 mol/l sodium hydroxide was added dropwise to the suspension. After heating the mixture for 2 hours in a steam bath with-stirring, the reaction mixture was cooled to room temperature, and 165 ml (1.90 mols) of concentrated hydrochloric acid was added dropwise to the mixture. The crystals formed were collected by filtration under a reduced pressure to provide 139.4 g (yield 87.4%) of 4-carboxymethyl-2-mercaptothiazole.

Provenance & Evidence