Hydrochloric Acid → HCID 178525233, compound

HRID 634959Notes

Reaction equation

HRID 634959 reaction equation
C([O:3][C:4]([CH2:6][C:7]1[N:8]=[C:9]([SH:12])[S:10][CH:11]=1)=[O:5])C.[OH-].[Na+].Cl>O>[C:4]([CH2:6][C:7]1[N:8]=[C:9]([SH:12])[S:10][CH:11]=1)([OH:5])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178470768HCID 178470768, compound

Product 1

HCID 178525233HCID 178525233, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In 366 ml of water was suspended 185 g (0.91 mol) of 4-ethoxycarbonylmethyl-2-mercaptothiazole and 366 ml (1.84 mols) of an aqueous solution of 5 mol/l sodium hydroxide was added dropwise to the suspension. After heating the mixture for 2 hours in a steam bath with-stirring, the reaction mixture was cooled to room temperature, and 165 ml (1.90 mols) of concentrated hydrochloric acid was added dropwise to the mixture. The crystals formed were collected by filtration under a reduced pressure to provide 139.4 g (yield 87.4%) of 4-carboxymethyl-2-mercaptothiazole.

Workup

  1. additionwas added dropwise to the suspension
  2. temperatureAfter heating the mixture for 2 hours in a steam bath
  3. customThe crystals formed
  4. filtrationwere collected by filtration under a reduced pressure

Sources & evidence

ORD record
ord-90a86f7235aa4c3d92910c4a571d06cf
Source dataset
uspto-grants-2001_02
Patent number
US06184386B2

Reaction notes

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