Glycine → HCID 131720460, compound

HRID 634994Notes

Reaction equation

HRID 634994 reaction equation
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[CH2:6]([N:8]([CH2:11][CH3:12])[CH2:9][CH3:10])[CH3:7].[F:13][C:14]([F:21])([F:20])[C:15](OCC)=[O:16]>CO>[CH2:6]([NH+:8]([CH2:11][CH3:12])[CH2:9][CH3:10])[CH3:7].[F:13][C:14]([F:21])([F:20])[C:15]([NH:1][CH2:2][C:3]([O-:5])=[O:4])=[O:16]

Participants

5

Reactant 3

HCID 750GlycineHCID 8471TriethylamineHCID 9794Ethyl trifluoroacetate

Product 1

HCID 131720460HCID 131720460, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of glycine (1.50 g, 20 mmol) in 100 ml dry methanol were added triethylamine (3.5 ml, 2.5 g, 25 mmol) and ethyl trifluoroacetate (3.0 ml, 3.55 g, 25 mmol). The mixture was stirred overnight to give a homogeneous solution. The solvents were removed and the resulting oil coevaporated with toluene to remove traces of methanol. The product was used without purification.

Workup

  1. customto give a homogeneous solution
  2. customThe solvents were removed
  3. customto remove traces of methanol
  4. customThe product was used without purification

Sources & evidence

ORD record
ord-958494822ddc4463a386c7e1b080ac66
Source dataset
uspto-grants-2001_02
Patent number
US06184389B2

Reaction notes

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