Methyl iodide → HCID 15524176, compound

Temperature

0 °C

The following reaction was carried out under a nitrogen atmosphere. At −78° C., n-butyl lithium (5.39 ml, 1.68 N, n-hexane solution, 9.06 mmol) was added dropwise to a tetrahydrofuran solution (40 ml) of diisopropylethylamine (1.37 ml, 9.75 mmol), and the mixture was warmed to 0C and stirred for 30 minutes. At −78° C., to this was further added dropwise a tetrahydrofuran solution (20 ml) of (4S)-4-(1-ethoxycarbonylcyclopropyl)-1-[(S)-1-phenylethyl]-2-pyrrolidone (2.10 g, 6.97 mmol). After an additional 15 minutes of stirring, methyl iodide (2.17 ml, 34.8 mmol) was added dropwise thereto, and the mixture was stirred for 30 minutes while warming to 0° C. After completing the reaction, this was cooled in an ice bath and mixed with a saturated ammonium chloride aqueous solution (150 ml) and then tetrahydrofuran was evaporated. The resulting residue was extracted with chloroform (150 ml×3), and the organic layer was dried over anhydrous sodium sulfate. After evaporating the solvent, the resulting residue was purified by a silica gel column chromatography (silica gel, 160 ml; ethyl acetate:hexane=2:3), to thereby obtain 1.90 g (87%) of the title compound.

1. customThe following reaction
2. stirringAfter an additional 15 minutes of stirring
3. stirringthe mixture was stirred for 30 minutes
4. customthe reaction
5. temperaturethis was cooled in an ice bath
6. customtetrahydrofuran was evaporated
7. extractionThe resulting residue was extracted with chloroform (150 ml×3)
8. dry with materialthe organic layer was dried over anhydrous sodium sulfate
9. customAfter evaporating the solvent
10. customthe resulting residue was purified by a silica gel column chromatography (silica gel, 160 ml; ethyl acetate:hexane=2:3)

ORD record

ord-0ad075e7eedd49a685b54f606403d5f0

Source dataset

uspto-grants-2001_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06184388B2