反应详情

20 mg of Pd/C (10%) is prehydrogenated for 20 minutes in 2 ml of absolute methanol. To it are added 200 mg (0.53 mmole) of the compound from Example 1 in a mixture of 2 ml of absolute methanol and 0.8 ml of ethyl acetate, and the mixture is hydrogenated for 1 hour at 20° C. The catalyst is filtered off, and the solvent is evaporated under vacuum in a rotary evaporator. The residue is pure in TLC and crystallizes upon drying under high vacuum.

1. filtrationThe catalyst is filtered off
2. customthe solvent is evaporated under vacuum in a rotary evaporator
3. customcrystallizes
4. customupon drying under high vacuum