2-(2-n-Propoxyphenyl)-8-(1-Hepten-1-yl)Quinazolin-4(3H)-One → 2-(2-n-Propoxyphenyl)-8-(1-Heptyl)quinazolin-4(3H)-One

HRID 635200Notes

Reaction equation

HRID 635200 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[NH:20][C:19](=[O:21])[C:18]2[C:13](=[C:14]([CH:22]=[CH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:15]=[CH:16][CH:17]=2)[N:12]=1)[CH2:2][CH3:3]>CO.C(OCC)(=O)C.[Pd]>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[NH:20][C:19](=[O:21])[C:18]2[C:13](=[C:14]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:15]=[CH:16][CH:17]=2)[N:12]=1)[CH2:2][CH3:3]

Participants

5

Reactant 1

HCID 1361324752-(2-n-Propoxyphenyl)-8-(1-Hepten-1-yl)Quinazolin-4(3H)-One

Product 1

HCID 1354446582-(2-n-Propoxyphenyl)-8-(1-Heptyl)quinazolin-4(3H)-One

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

20 mg of Pd/C (10%) is prehydrogenated for 20 minutes in 2 ml of absolute methanol. To it are added 200 mg (0.53 mmole) of the compound from Example 1 in a mixture of 2 ml of absolute methanol and 0.8 ml of ethyl acetate, and the mixture is hydrogenated for 1 hour at 20° C. The catalyst is filtered off, and the solvent is evaporated under vacuum in a rotary evaporator. The residue is pure in TLC and crystallizes upon drying under high vacuum.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is evaporated under vacuum in a rotary evaporator
  3. customcrystallizes
  4. customupon drying under high vacuum

Sources & evidence

ORD record
ord-37c2a1f27a114f1998d999cab80bc48e
Source dataset
uspto-grants-2001_02
Patent number
US06187779B1

Reaction notes

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