Hydrazine hydrate (1:1) → 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid

HRID 635268Notes

Reaction equation

HRID 635268 reaction equation
O.[NH2:2][NH2:3].O=[C:5]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C:12]1=O)[CH2:6][CH2:7][C:8]([OH:10])=[O:9]>C(O)C>[N:2]1[NH:3][C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[C:11]2[C:12]=1[CH2:13][CH2:14][CH2:15][CH2:16]2

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 36291314-Oxo-4-(2-oxocyclohexyl)butyric acid

Product 1

HCID 1785253693-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acidYield 97.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine hydrate (1.1 g) was added to a solution (40 ml) of 4-oxo-4-(2-oxocyclohexyl)-n-butyric acid (4.1 g) in ethanol and the mixture was refluxed for 1 hour. After the completion of the reaction, the reaction mixture was cooled and the precitated crystals were collected by filtration to give 3.9 g of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid, m.p. 135-136° C.

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. customAfter the completion of the reaction
  3. temperaturethe reaction mixture was cooled
  4. filtrationthe precitated crystals were collected by filtration

Sources & evidence

ORD record
ord-25af7388b69b40489a2e69041c91f84e
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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