2,2-Dimethyl-1,3-dioxane-4,6-dione → 3-(3-(4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridin-1-yl)propyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine

HRID 635299Notes

Reaction equation

HRID 635299 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]=12.CC1(C)O[C:16](=O)[CH2:15][C:14](=O)O1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH:33]=2)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH2:33][CH2:32][N:31]([CH2:16][CH2:15][CH2:14][C:3]3[N:4]4[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]4=[N:1][CH:2]=3)[CH2:30][CH:29]=2)=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 1857174-(4-Chlorophenyl)-1,2,3,6-tetrahydropyridineHCID 102611496,7,8,9-Tetrahydro-5H-imidazo[1,2-a]azepine

Product 1

HCID 599393673-(3-(4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridin-1-yl)propyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine

Procedure

By the same reaction and treatment as in Example 91 using 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine, 2,2-dimethyl-1,3-dioxane-4,6-dione and 4-(4chlorophenyl)-1,2,3,6-tetrahydropyridine, 3-(3-(4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridin-1-yl)propyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine is obtained.

Sources & evidence

ORD record
ord-5a85395a58a84a43b754018c0bf7f55f
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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