1-(4-Fluorophenyl)piperazine → 3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)-4,5,6,7-tetrahydro-2H-indazole

HRID 635308Notes

Reaction equation

HRID 635308 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[N:14]1[NH:15][C:16]([CH2:23][CH2:24][C:25](O)=O)=[C:17]2[C:22]=1[CH2:21][CH2:20][CH2:19][CH2:18]2.Cl[C:29]1C=CC(C2CCNCC2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:29][CH2:25][CH2:24][CH2:23][C:16]3[NH:15][N:14]=[C:22]4[C:17]=3[CH2:18][CH2:19][CH2:20][CH2:21]4)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 752601-(4-Fluorophenyl)piperazineHCID 12036134-(4-Chlorophenyl)piperidineHCID 1785253693-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid

Product 1

HCID 1785058563-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)-4,5,6,7-tetrahydro-2H-indazole

Procedure

In the same manner as in Example 102 except that 4-(4,5,6,7-tetrahydro-2H-indazol-3-yl)-n-butyric acid obtained in Starting Material Synthesis Example 3 and 1-(4-fluorophenyl)piperazine were used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 1 and 4-(4-chlorophenyl)piperidine, 3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)-4,5,6,7-tetrahydro-2H-indazole was obtained.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-bbaffbc4a16f4dac8077f451fa097f83
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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