HCID 178505853, compound → HCID 178505854, compound

HRID 635313Notes

Reaction equation

HRID 635313 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]2=[N:14][NH:15][C:16]([CH2:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][N:23]([C:26]4[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=4)[CH2:22][CH2:21]3)=[C:10]2[CH2:9]1)C1C=CC=CC=1>C(O)C.[Ni]>[F:32][C:29]1[CH:28]=[CH:27][C:26]([N:23]2[CH2:22][CH2:21][N:20]([CH2:19][CH2:18][CH2:17][C:16]3[NH:15][N:14]=[C:11]4[CH2:12][CH2:13][NH:8][CH2:9][C:10]=34)[CH2:25][CH2:24]2)=[CH:31][CH:30]=1

Participants

4

Reactant 1

HCID 178505853HCID 178505853, compound

Product 1

HCID 178505854HCID 178505854, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

5-Benzyl-3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine (0.5 g) obtained in Example 139 was dissolved in ethanol (10 ml), and Raney nickel (0.2 g) was added to perform catalytic reduction. After the completion of the reaction, the reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine,

Workup

  1. customAfter the completion of the reaction
  2. filtrationthe reaction mixture was filtered through celite
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4c44d1b485b34f7ba5034e4af75bc986
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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