1-(4-Fluorophenyl)piperazine → HCID 17773186, compound

HRID 635319Notes

Reaction equation

HRID 635319 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[N:14]1[NH:15][C:16]([CH2:23][CH2:24][C:25](O)=O)=[C:17]2[C:22]=1[CH2:21][CH2:20][CH2:19][CH2:18]2.ClC1C=CC([CH:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:25][CH2:24][CH2:23][C:16]3[N:15]([C:37]4[CH:36]=[CH:35][CH:40]=[CH:39][N:38]=4)[N:14]=[C:22]4[C:17]=3[CH2:18][CH2:19][CH2:20][CH2:21]4)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 752601-(4-Fluorophenyl)piperazineHCID 12036134-(4-Chlorophenyl)piperidineHCID 1785253693-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid

Product 1

HCID 17773186HCID 17773186, compound

Procedure

In the same manner as in Example 102 except that 3-(4,5,6,7-tetrahydro-2-(2-pyridyl)-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 10 and 1-(4-fluorophenyl)piperazine are used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 1 and 4-(4-chlorophenyl)piperidine, 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-2-(2-pyridyl)-2H-indazole is obtained.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-236060a4747b48ba83689ca570e66a05
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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