Ethyl orthoformate → Allyl 3-(methylamino)benzoate

HRID 635407Notes

Reaction equation

HRID 635407 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5]([O:7][CH2:8][CH:9]=[CH2:10])=[O:6].[CH:14](OCC)(OCC)OCC>FC(F)(F)C(O)=O>[CH3:14][NH:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5]([O:7][CH2:8][CH:9]=[CH2:10])=[O:6]

Participants

4

Reactant 2

HCID 31214Ethyl orthoformateHCID 18930599Allyl 3-aminobenzoate

Product 1

HCID 22168609Allyl 3-(methylamino)benzoateYield 17%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidCatalyst

Procedure

Allyl 3-aminobenzoate (5 g, 28.2 mN) was dissolved in triethyl orthoformate (50 ml) and trifluoroacetic acid (5 drops) was added. The solution was stirred and refluxed up through 3a molecular sieves for 5 hours. Solvent was removed, and the residue dissolved in ethanol (50 ml), followed by the addition of acetic acid (8.08 ml) and sodium cyanoborohydride (6.85 g, 0.108 M) in several portions. The mixture was stirred at ambient temperature for 16 hours, and solvent removed. The residue was dissolved in diethyl ether, washed with water, brine, and dried over MgSO4. Crude product was purified by chromatography on silica, eluting with a gradient from dichloromethane to dichloromethane/ethyl acetate (95:5), to give allyl 3-methylaminobenzoate (0.93 g, 17%). Nmr (CDCl3): δ 2.88 (s, 3H); 4.81 (dt, 2H); 5.23-5.45 (m, 2H); 5.94-6.13 (m, 1H); 6.83 (dd, 1H); 7.25 (dd, 1H); 7.33 (t, 1H); 7.43 (dm, 1H).

Workup

  1. customSolvent was removed
  2. dissolutionthe residue dissolved in ethanol (50 ml)
  3. additionfollowed by the addition of acetic acid (8.08 ml) and sodium cyanoborohydride (6.85 g, 0.108 M) in several portions
  4. stirringThe mixture was stirred at ambient temperature for 16 hours
  5. customsolvent removed
  6. dissolutionThe residue was dissolved in diethyl ether
  7. washwashed with water, brine
  8. dry with materialdried over MgSO4
  9. customCrude product was purified by chromatography on silica
  10. washeluting with a gradient from dichloromethane to dichloromethane/ethyl acetate (95:5)

Sources & evidence

ORD record
ord-4dc3623ad7b84d67bbb53bd8ae54d858
Source dataset
uspto-grants-2001_02
Patent number
US06187804B1

Reaction notes

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