1,4-Dioxane hydrochloride → HCID 69992378, compound

HRID 635426Notes

Reaction equation

HRID 635426 reaction equation
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][NH:17][CH2:18][C@@H:19]([C:28]1[CH:29]=[CH:30][C:31]([Cl:39])=[C:32]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])[CH:33]=1)[O:20][Si](CC)(CC)CC.Cl.O1CCOCC1>O1CCCC1>[ClH:39].[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][NH:17][CH2:18][C@@H:19]([C:28]1[CH:29]=[CH:30][C:31]([Cl:39])=[C:32]([NH:34][S:35]([CH3:38])(=[O:36])=[O:37])[CH:33]=1)[OH:20]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54183074HCID 54183074, compound

Product 1

HCID 69992378HCID 69992378, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Intermediate 108 (73.2 mg) was dissolved in anhydrous tetrahydrofuran (4.2ml), whereto 4 N hydrogenchloride/1,4-dioxane (240 μl ) was added and the mixture was agitated at room temperature for 1 hour. The deposited precipitate was taken out and washed with tetrahydrofuran, whereupon it was dried under a reduced pressure at 40° C., whereby the above-identified compound was obtained (36.3 mg).

Workup

  1. washwashed with tetrahydrofuran, whereupon it
  2. customwas dried under a reduced pressure at 40° C.
  3. customwhereby the above-identified compound was obtained (36.3 mg)

Sources & evidence

ORD record
ord-dc24f75708a94124b5de8df8fe3822b1
Source dataset
uspto-grants-2001_02
Patent number
US06187809B1

Reaction notes

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