反应详情

Diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate (20 g) was added to a 5N aqueous hydrochloric acid solution (350 ml) and the mixture was refluxed under heating for 6.5 hours. Ethanol (45 ml) was added to the mixture and the whole mixture was further refluxed under heating for 1.5 hours. The reaction mixture was concentrated under reduced pressure to give the subject compound (20 g). MS: 292(M+).

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 6.5 hours
3. temperaturethe whole mixture was further refluxed
4. temperatureunder heating for 1.5 hours
5. concentrationThe reaction mixture was concentrated under reduced pressure