Methanol → Methyl 2-amino-4-(4-octylphenyl)butyrate hydrochloride

HRID 635459Notes

Reaction equation

HRID 635459 reaction equation
[ClH:1].[NH2:2][CH:3]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][CH:10]=1)[C:4]([OH:6])=[O:5].[CH3:23]O>S(Cl)(Cl)=O>[ClH:1].[NH2:2][CH:3]([CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:13][CH:14]=1)[C:4]([O:6][CH3:23])=[O:5]

Participants

4

Reactant 2

HCID 887MethanolHCID 701487132-Amino-4-(4-octylphenyl)butanoic acid hydrochloride

Product 1

HCID 22618877Methyl 2-amino-4-(4-octylphenyl)butyrate hydrochloride

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

To a solution of 2-Amino-4-(4-octylphenyl)butanoic acid hydrochloride (20 g) in methanol (500 ml), thionyl chloride (7.2 ml) was added under ice-cooling and the mixture was left standing overnight. The reaction mixture was concentrated under reduced pressure to give the subject compound (16 g). MS: 305(M+).

Workup

  1. temperaturecooling
  2. waitthe mixture was left
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-453bd35cef7044e6bbc7ded006f87dbd
Source dataset
uspto-grants-2001_02
Patent number
US06187821B1

Reaction notes

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