HRID635497

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID8502

4-Nitrobenzoyl chloride

C7H4ClNO3

结构：O=C(Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O1)c1ccccc1

HCID107558

N-Benzoyl-2'-deoxyadenosine

C17H17N5O4

PRODUCTS

生成物

结构：O=C(Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COC(=O)c2ccc([N+](=O)[O-])cc2)O1)c1ccccc1

HCID15382693

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

2 次

PROCEDURE

实验过程

The synthesis of this product is carried out by reacting 1 eq of p-nitrobenzoyl chloride with 6-N-benzoyldeoxyadenosine for 4 hours in pyridine. After hydrolysis of the excess reagent, partial evaporation of the pyridine, extraction and evaporation of the chloroformic phase, the product is obtained by column chromatography (elution 4% methanol).

WORKUP

后处理

customThe synthesis of this product
customfor 4 hours

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5abaca9d871242a3abe42dc791ab9001
来源数据集: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06187914B1
来源说明: uspto-grants-2001_02

反应 SMILES

[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:13]([NH:21][C:22]1[C:23]2[N:24]=[CH:25][N:26]([C:35]=2[N:36]=[CH:37][N:38]=1)[C@@H:27]1[O:34][C@H:31]([CH2:32][OH:33])[C@@H:29]([OH:30])[CH2:28]1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CO>N1C=CC=CC=1>[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([O:33][CH2:32][C@H:31]2[O:34][C@@H:27]([N:26]3[C:35]4[N:36]=[CH:37][N:38]=[C:22]([NH:21][C:13](=[O:20])[C:14]5[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=5)[C:23]=4[N:24]=[CH:25]3)[CH2:28][C@@H:29]2[OH:30])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]