HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzoyl chloride → 5'-O-p-Nitrobenzoyl-2-N-Isobutyryldeoxyguanosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| Reactant | Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)- | HCID 135407017 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5'-O-p-Nitrobenzoyl-2-N-Isobutyryldeoxyguanosine | HCID 137182964 | — |
Reaction Steps
The synthesis of this product is carried out by reacting 1.1 eq of p-nitrobenzoyl chloride with 2-N-isobutyryldeoxyguanosine for 16 hours in pyridine. After extraction with a dichloromethane/sodium bicarbonate mixture and evaporation to dryness, the product is taken up in chloroform. This product was not used because it was too insoluble.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06187914B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-9a69e84c0a0941aaba3f666c4f9434bd |
| Source note | uspto-grants-2001_02 |