Ethyl chloroacetate → HCID 70223099, compound

Participants

Reaction Steps

The synthesis of this product required the preparation of t-butylphenoxyacetyl chloride from sodium t-butylphenoxide and ethyl chloroacetate. The ethyl t-butylphenoxyacetate obtained is cleaved with potassium hydroxide in order to liberate the t-butylphenoxyacetic acid. The acid chloride is obtained by heating this acid in thionyl chloride. After removing the excess thionyl chloride, the t-butylphenoxyacetyl chloride is reacted with deoxyguanosine according to the procedure described by SCHULHOF et al. for 2-N-phenoxyacetyldeoxyguanosine [Nucleic Acids Res., 15(2), p. 397-415, (1987)].

Provenance & Evidence