Hydrochloric Acid → 2-Chloro-1-phenylethanol, (+)-
Reaction equation
[CH2:1]([Cl:10])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3].Cl>O>[Cl:10][CH2:1][C@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
After preparing the reducing agent by the same method as described in Example 1. 1.55 g (10 mmol) of phenacyl chloride was added to the reducing agent and the mixture was stirred at 50° C. for 2 hours. To the mixture were added 2 ml of 1N hydrochloric acid and 20 ml of water to conduct hydrolysis. The mixture was extracted with ethyl acetate and concentrated to obtain an oily product. The obtained oil was analyzed by HPLC.
Workup
- customAfter preparing the reducing agent by the same method
- customhydrolysis
- extractionThe mixture was extracted with ethyl acetate
- concentrationconcentrated
- customto obtain an oily product
Sources & evidence
- ORD record
- ord-adc42e2b7ceb4c0bbe08e575c001fb21
- Source dataset
- uspto-grants-2001_02
- Patent number
- US06187966B1
Reaction notes
Loading…