Diethyl Ether → HCID 21258943, compound

HRID 635633Notes

Reaction equation

HRID 635633 reaction equation
C(OC([NH:8][CH:9]([CH2:15][C:16]([F:19])([F:18])[F:17])[CH:10]([OH:14])[C:11]([NH2:13])=[O:12])=O)(C)(C)C.O.[C:21]1([CH3:31])[CH:26]=[CH:25][C:24]([S:27]([OH:30])(=[O:29])=[O:28])=[CH:23][CH:22]=1.C(OCC)C>C(#N)C>[C:21]1([CH3:31])[CH:22]=[CH:23][C:24]([S:27]([OH:30])(=[O:28])=[O:29])=[CH:25][CH:26]=1.[NH2:8][CH:9]([CH2:15][C:16]([F:17])([F:18])[F:19])[CH:10]([OH:14])[C:11]([NH2:13])=[O:12]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 521998p-Toluenesulfonic acid monohydrateHCID 21258912HCID 21258912, compound

Product 1

HCID 21258943HCID 21258943, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 580 mg (2.03 mmol) of 3(RS)-(tert-butoxyformamido)-5,5,5-trifluoro-2(RS)-hydroxyvaleramide and 1.16 g (6.11 mmol) of 4-toluenesulphonic acid monohydrate in 10 ml of acetonitrile was stirred until the reaction had finished according to thin-layer chromatography. 10 ml of diethyl ether were added and the 3(RS)-amino-5,5,5-trifluoro-2(RS)-hydroxyvaleramide p-toluenesulphonate (1:1) which formed was removed by filtration and added to a solution of 1.06 g (1.156 mmol) of N-[N-[N-[N-[N-[3-(tert-butoxycarbonyl)propionyl]-O-tert-butyl-L-α-aspartyl]-O-tert-butyl-L-α-glutamyl]-2-methyl-L-phenylalanyl]-3-methyl-L-valyl]-L-leucine (prepared as described in Example 1), 321 mg (2.79 mmol) of N-ethylmorpholine, 268 mg (1.4 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 190 mg (1.4 mmol) of 1-hydroxy-7-azabenzotriazole in 20 ml of dichloromethane. The mixture was stirred at room temperature until the reaction had finished according to thin-layer chromatography. The solution was washed with 2M hydrochloric acid and saturated sodium bicarbonate solution, then dried over anhydrous magnesium sulphate, filtered and evaporated to dryness. The residue was triturated with diethyl ether/petroleum ether (1:1) and the solid was removed by filtration to give 0.7 g of 3(RS)-[[N-[N-[N-[N-[N-[3-(tert-butoxycarbonyl)propionyl]-O-tert-butyl-L-α-aspartyl]-O-tert-butyl-L-α-glutamyl]-2-methyl-L-phenylalanyl]-3-methyl-L-valyl]-L-leucyl]amino]-5,5,5-trifluoro-2(RS)-hydroxyvaleramide as a white solid, MS: m/e 1086.6 [M+H]+.

Sources & evidence

ORD record
ord-1f5a172a8f4f4a8f8e33ddc492dca97f
Source dataset
uspto-grants-2001_02
Patent number
US06187905B1

Reaction notes

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