反应详情

3 g of 2-aminophenol is mixed in 23 ml of toluene with 1.8 g of sodium hydride with the addition of 50 mg of TEBA (triethylbenzylammonium chloride), and 4.4 ml of 2-bromo-2-methylpropionic acid ethyl ester is added drop by drop at ice bath temperature. After 2 hours at room temperature, it is poured onto ice water, extracted with ethyl acetate, washed with brine, the organic phase is dried with magnesium sulfate and concentrated by evaporation. After recrystallization from isopropyl ether, 278 mg of crystals results.

1. additionis added drop by drop at ice bath temperature
2. additionit is poured onto ice water
3. extractionextracted with ethyl acetate
4. washwashed with brine
5. dry with materialthe organic phase is dried with magnesium sulfate
6. concentrationconcentrated by evaporation
7. customAfter recrystallization from isopropyl ether, 278 mg of crystals
8. customresults