Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

HRID 635799Notes

Reaction equation

HRID 635799 reaction equation
[N:1]1[NH:2][C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([N:2]1[C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=[N:1]1)(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 680371,2,4-Triazine-3,5(2H,4H)-dione

Product 1

HCID 212565952-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

Procedure

2H-[1,2,4]Triazin-3,5-dione (100 g, 884 mmol) is placed in 600 ml of acetic anhydride at reflux for 1.5 h. The reaction mixture is subsequently concentrated to dryness and the solid obtained is triturated in toluene. After filtering and rinsing with toluene, 130.5 g of beige crystals are isolated.

Workup

  1. temperatureat reflux for 1.5 h
  2. concentrationThe reaction mixture is subsequently concentrated to dryness
  3. customthe solid obtained
  4. customis triturated in toluene
  5. filtrationAfter filtering
  6. washrinsing with toluene, 130.5 g of beige crystals
  7. customare isolated

Sources & evidence

ORD record
ord-a31f88d4691e424dbd6d44686bd27d99
Source dataset
uspto-grants-2001_02
Patent number
US06191130B1

Reaction notes

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