Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

Participants

Reaction Steps

2H-[1,2,4]Triazin-3,5-dione (100 g, 884 mmol) is placed in 600 ml of acetic anhydride at reflux for 1.5 h. The reaction mixture is subsequently concentrated to dryness and the solid obtained is triturated in toluene. After filtering and rinsing with toluene, 130.5 g of beige crystals are isolated.

Provenance & Evidence