1-Chloroethyl chloroformate → HCID 178521569, compound

HRID 635800Notes

Reaction equation

HRID 635800 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C@@H:14]2[CH2:19][CH2:18][C@H:17]([OH:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C(N1CCN(C2CCC(=O)CC2)CC1)C1C=CC=CC=1.ClC(OC(Cl)C)=O>ClCCl>[N:11]1([C@@H:14]2[CH2:15][CH2:16][C@H:17]([OH:20])[CH2:18][CH2:19]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 5213051-Chloroethyl chloroformateHCID 15338143HCID 15338143, compoundHCID 178521571HCID 178521571, compound

Product 1

HCID 178521569HCID 178521569, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

cis-4-(4-Benzylpiperizin-1-yl)cyclohexanol (prepared according to the process described in Example 5 using 4-(4-benzylpiperizin-1-yl)cyclohexanone in Stage a) (11.6 g, 30.3 mmol) is placed in 80 ml of dichloromethane at 0° C. α-Chloroethyl chloroformate (9.9 ml, 90.9 mmol) is run in dropwise and the mixture is stirred for 0.5 h at 0° C.

Sources & evidence

ORD record
ord-fd5100a0d12e4ceb83d2286f20188e73
Source dataset
uspto-grants-2001_02
Patent number
US06191130B1

Reaction notes

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