1-Chloroethyl chloroformate → HCID 178521569, compound

Participants

Reaction Conditions

Reaction Steps

cis-4-(4-Benzylpiperizin-1-yl)cyclohexanol (prepared according to the process described in Example 5 using 4-(4-benzylpiperizin-1-yl)cyclohexanone in Stage a) (11.6 g, 30.3 mmol) is placed in 80 ml of dichloromethane at 0° C. α-Chloroethyl chloroformate (9.9 ml, 90.9 mmol) is run in dropwise and the mixture is stirred for 0.5 h at 0° C.

Provenance & Evidence