Aluminium lithium hydride → HCID 21256481, compound

Participants

Reaction Steps

A suspension of LiAlH4 (2.1 g) in THF (100 mL) was treated with 5,6,7,8-Tetrahydro-imidazo[2,1-b]benzothiazole-3-carboxylic acid ethyl ester (Formula F-4) (5.6 g) and reacted at 25° C. for 5.5 hours. The reaction was quenched by serial additions of water and 15% sodium hydroxide and the mixture was filtered. Evaporation of the filtrate gave 5,6,7,8-Tetrahydro-imidazo[2,1-b]benzothiazole-3-methanol (Formula F-5) (4.11 g), m.p. 182-183° after crystallization from iso-propanol.

Provenance & Evidence