Aluminium lithium hydride → HCID 21256481, compound

HRID 635854Notes

Reaction equation

HRID 635854 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].C([O:9][C:10]([C:12]1[N:19]2[C:15]([S:16][C:17]3[CH2:23][CH2:22][CH2:21][CH2:20][C:18]=32)=[N:14][CH:13]=1)=O)C>C1COCC1>[N:14]1[CH:13]=[C:12]([CH2:10][OH:9])[N:19]2[C:18]3[CH2:20][CH2:21][CH2:22][CH2:23][C:17]=3[S:16][C:15]=12

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 54044379HCID 54044379, compound

Product 1

HCID 21256481HCID 21256481, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of LiAlH4 (2.1 g) in THF (100 mL) was treated with 5,6,7,8-Tetrahydro-imidazo[2,1-b]benzothiazole-3-carboxylic acid ethyl ester (Formula F-4) (5.6 g) and reacted at 25° C. for 5.5 hours. The reaction was quenched by serial additions of water and 15% sodium hydroxide and the mixture was filtered. Evaporation of the filtrate gave 5,6,7,8-Tetrahydro-imidazo[2,1-b]benzothiazole-3-methanol (Formula F-5) (4.11 g), m.p. 182-183° after crystallization from iso-propanol.

Workup

  1. customreacted at 25° C. for 5.5 hours
  2. customThe reaction was quenched by serial additions of water and 15% sodium hydroxide
  3. filtrationthe mixture was filtered
  4. customEvaporation of the filtrate

Sources & evidence

ORD record
ord-278e02b5189e496c8a4ef1709c845cd5
Source dataset
uspto-grants-2001_02
Patent number
US06191124B1

Reaction notes

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