3-Fluorobenzaldehyde → 3-(3-Fluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one

HRID 635869Notes

Reaction equation

HRID 635869 reaction equation
[N:1]1[CH:2]=[C:3]([C:14](=[O:16])[CH3:15])[N:4]2[C:8]3[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:7]=3[S:6][C:5]=12.[F:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH:21]=O>>[F:17][C:18]1[CH:19]=[C:20]([CH:21]=[CH:15][C:14]([C:3]2[N:4]3[C:5]([S:6][C:7]4[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]=43)=[N:1][CH:2]=2)=[O:16])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 212564561-(6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-ethanone

Product 1

HCID 700570593-(3-Fluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one

Procedure

[1-(6,7,8,9-Tetrahydro-5H-cyclohept[d]-imidazo[2,1-b]thiazol-3-yl)-ethanone (Formula N-4), 2.34 g and 3-fluorobenzaldehyde were reacted using non-critical variations of the teachings Example 15 to give 3-(3-fluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept [d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one (Formula N-5, X=3-fluoro), 3.08 g, m.p. 176-177°.

Sources & evidence

ORD record
ord-e4cf30db69904b6e8f4840fdc3e309dd
Source dataset
uspto-grants-2001_02
Patent number
US06191124B1

Reaction notes

Loading…