HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzaldehyde → 3-(3-Fluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzaldehyde | HCID 68009 | — |
| Reactant | 1-(6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-ethanone | HCID 21256456 | — |
| Product | 3-(3-Fluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one | HCID 70057059 | — |
Reaction Steps
[1-(6,7,8,9-Tetrahydro-5H-cyclohept[d]-imidazo[2,1-b]thiazol-3-yl)-ethanone (Formula N-4), 2.34 g and 3-fluorobenzaldehyde were reacted using non-critical variations of the teachings Example 15 to give 3-(3-fluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept [d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one (Formula N-5, X=3-fluoro), 3.08 g, m.p. 176-177°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06191124B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-e4cf30db69904b6e8f4840fdc3e309dd |
| Source note | uspto-grants-2001_02 |