HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorobenzaldehyde → 3-(3,5-Difluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorobenzaldehyde | HCID 588160 | — |
| Reactant | 1-(6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-ethanone | HCID 21256456 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3,5-Difluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one | HCID 54261144 | — |
Reaction Steps
1-(6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-ethanone (Formula N-4, 1.8 g in THF (50 mL) was condensed with 3,5-difluorobenzaldehyde according to non-critical variations in PREPARATION 15 to yield pure 3-(3,5-Difluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one (Formula N-5, X=3,5-difluoro), 0.51 g, m.p. 207-209°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06191124B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-219d7af4a5cc40c286f1338585650b04 |
| Source note | uspto-grants-2001_02 |