3,5-Difluorobenzaldehyde → HCID 54261144, compound

HRID 635874Notes

Reaction equation

HRID 635874 reaction equation
[N:1]1[CH:2]=[C:3]([C:14](=[O:16])[CH3:15])[N:4]2[C:8]3[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:7]=3[S:6][C:5]=12.[F:17][C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([F:26])[CH:25]=1)[CH:21]=O>C1COCC1>[F:17][C:18]1[CH:19]=[C:20]([CH:21]=[CH:15][C:14]([C:3]2[N:4]3[C:5]([S:6][C:7]4[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]=43)=[N:1][CH:2]=2)=[O:16])[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

4

Reactant 2

HCID 5881603,5-DifluorobenzaldehydeHCID 212564561-(6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-ethanone

Product 1

HCID 54261144HCID 54261144, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-(6,7,8,9-Tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-ethanone (Formula N-4, 1.8 g in THF (50 mL) was condensed with 3,5-difluorobenzaldehyde according to non-critical variations in PREPARATION 15 to yield pure 3-(3,5-Difluorophenyl)-1-(6,7,8,9-tetrahydro-5H-cyclohept[d]imidazo[2,1-b]thiazol-3-yl)-2-propene-1-one (Formula N-5, X=3,5-difluoro), 0.51 g, m.p. 207-209°.

Workup

  1. customin PREPARATION 15

Sources & evidence

ORD record
ord-219d7af4a5cc40c286f1338585650b04
Source dataset
uspto-grants-2001_02
Patent number
US06191124B1

Reaction notes

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