反应详情

温度

65 °C

(Step 2) A mixture of 145 g of ethyl 3-(4-fluorophenyl)-3-oxopropionate, 97.8 g of acetamidine hydrochloride, 191 g of powdered potassium carbonate, and 1.16 L of ethanol was stirred at 60-70° C. for 16 hours. This reaction mixture was filtered to remove insolubles and the filtrate was concentrated. To the residue was added water and the resultant was neutralized with acetic acid. The crystals that separated out were collected by filtration, washed with water, and dried to provide 88.7 g of the title compound as white crystals. m.p. 290-292° C. (decomp.)

1. filtrationThis reaction mixture was filtered
2. customto remove insolubles
3. concentrationthe filtrate was concentrated
4. additionTo the residue was added water
5. customThe crystals that separated out
6. filtrationwere collected by filtration
7. washwashed with water
8. customdried