反应详情

To 21 g of 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine was added 63 ml of phosphorus oxychloride and the mixture was refluxed for 1 hour. This reaction mixture was cooled, poured into iced water, and neutralized with 28% aqueous ammonia and the crystals that separated out were collected by filtration. The crystals were washed with water and dried to provide 21 g of the title compound.

1. temperaturethe mixture was refluxed for 1 hour
2. temperatureThis reaction mixture was cooled
3. customthe crystals that separated out
4. filtrationwere collected by filtration
5. washThe crystals were washed with water
6. customdried