Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(4-Fluoro-phenyl)-butane-1,3-dione | HCID 432655 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine | HCID 178422714 | 46.9% |
반응 단계
A mixture of 5 g of 4-fluorobenzoylacetone, 1.66 g of urea, 25 ml of ethanol, and 3.8 ml of concentrated hydrochloric acid was refluxed for 20 hours. This reaction mixture was cooled, poured into iced water, made basic with aqueous solution of potassium carbonate, and neutralized with acetic acid. The crystals that separated out were collected by filtration, washed with isopropyl ether, and dried to provide 2.65 g of pale yellow crystals. m.p. 265-268° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06191149B1 |
| 출처 데이터셋 | uspto-grants-2001_02 |
| ORD ID | ord-0c87bdaf0e5c4bbc85733afaad7cc70b |
| 출처 메모 | uspto-grants-2001_02 |