Hydroxyamine hydrochloride → HCID 131722394, compound

HRID 635907Notes

Reaction equation

HRID 635907 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][C:9]([CH3:15])([CH3:14])[C:8](=O)[CH2:7]2)([OH:3])=[O:2].Cl.[NH2:18][OH:19]>C(O)C.N1C=CC=CC=1>[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][C:9]([CH3:15])([CH3:14])[CH2:8][C:7]2=[N:18][OH:19])([OH:3])=[O:2]

Participants

5

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 21257118HCID 21257118, compound

Product 1

HCID 131722394HCID 131722394, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1049PyridineSolvent

Conditions

Temperature
80 °C

Procedure

14.9 g of 6-carboxy-2,2-dimethyl-3-chromanone are dissolved in 100 ml of ethanol and 100 ml of pyridine, and after addition of 5.16 g of hydroxylamine hydrochloride the mixture is heated at 80° C. with stirring for 6 hours. The solvent is distilled off on a rotary evaporator. The residue is treated with water and adjusted to pH<1 using conc. hydrochloric acid, and the colorless crystals are filtered off.

Workup

  1. distillationThe solvent is distilled off on a rotary evaporator
  2. additionThe residue is treated with water
  3. filtrationthe colorless crystals are filtered off

Sources & evidence

ORD record
ord-d452c6351e804a80bddc69fe5df7cc03
Source dataset
uspto-grants-2001_02
Patent number
US06191164B1

Reaction notes

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