Hydrochloric Acid → HCID 21256678, compound

HRID 635970Notes

Reaction equation

HRID 635970 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:17](=[O:19])[CH2:16][N:15](C(OC=C)=O)[CH2:14][C:13]=3[NH:12][C:11]3[CH2:25][N:26](C(OC=C)=O)[CH2:27][C:28](=[O:29])[C:10]2=3)[CH:5]=[CH:6][C:7]=1[F:8].[ClH:35].CCOCC>C(O)C>[ClH:35].[ClH:35].[Br:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:17](=[O:19])[CH2:16][NH:15][CH2:14][C:13]=3[NH:12][C:11]3[CH2:25][NH:26][CH2:27][C:28](=[O:29])[C:10]2=3)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 11421239HCID 11421239, compound

Product 1

HCID 21256678HCID 21256678, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the product from Example 4B (0.22 g, 0.41 mmol) in ethyl alcohol (5 mL) was treated with concentrated hydrochloric acid (0.10 mL) refluxed for 3 hours, allowed to cool to ambient temperature and treated with ether. The resulting solid precipitate was collected and dried to provide the title compound (0.12 g).

Workup

  1. temperaturerefluxed for 3 hours
  2. customThe resulting solid precipitate was collected
  3. customdried

Sources & evidence

ORD record
ord-6de0ad1350954a33883d41c30addc6b0
Source dataset
uspto-grants-2001_02
Patent number
US06191140B1

Reaction notes

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