Sodium Hydroxide → 3-phenyl-5-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine

HRID 63599Notes

Reaction equation

HRID 63599 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[N:11][CH:12]=[C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[O:22][CH3:23])[CH:14]=3)[N:9](S(C3C=CC=CC=3)(=O)=O)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([C:7]2[C:15]3[C:10](=[N:11][CH:12]=[C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[O:22][CH3:23])[CH:14]=3)[NH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 90239025HCID 90239025, compound

Product 1

HCID 727926883-phenyl-5-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 3-phenyl-5-(2-methoxyphenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (374 mg, 0.85 mmol) in methanol (2.3 ml) is added NaOH (260 μl of 2 N solution in water, 0.51 mmol). The mixture is heated at 80° C. for 1 hour and then cooled at room temperature.

Workup

  1. temperaturecooled at room temperature

Sources & evidence

ORD record
ord-f7d8d3f9edf343c89ac88e5f318006dd
Source dataset
uspto-grants-2016_09
Patent number
US09447093B2

Reaction notes

Loading…