Thiophenol → HCID 18466516, compound

HRID 636065Notes

Reaction equation

HRID 636065 reaction equation
F[C:2]1[C:7]([F:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.[C:10]1([SH:16])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>[Cu]>[Cl:9][C:5]1[CH:6]=[C:7]([F:8])[C:2]([S:16][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:3][CH:4]=1

Participants

4

Reactant 2

HCID 7969ThiophenolHCID 27832485-Chloro-2,3-difluoropyridine

Product 1

HCID 18466516HCID 18466516, compound

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Conditions

Temperature
185 °C

Procedure

Starting from 93 g (0.508 mol) of 2,3-difluoro-5-chloropyridine, 58.8 g (0.5276 mol) of 98.7% pure thiophenol and 3.2 mg (0.01 mol %) of copper powder which were stirred in a pressure apparatus at 185° C. for 1.5 h and worked up by the method of Example 1, 121.5 g (99.9% of theory) of the title compound were obtained as a colorless oil. 1H-NMR (ppm, d6DMSO) 8.35 (s/1H), 8.05 (d/1H), 7.4-7.6 (m/5H).

Sources & evidence

ORD record
ord-2de4c54c9f25433ebd635abf6d4e93d6
Source dataset
uspto-grants-2001_02
Patent number
US06191280B1

Reaction notes

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